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I am female, 41, have been taking methotrexate for 2 months now. I was crippled, my hands fingers wrists ankles balls of my feet knees shoulders arms even my jaw. I could barely walk I couldn't unscrew lids, peel potatoes, do everyday chores people take for granted. My rheumatoid factor was 1380. After 1 month no change hopefully my 2nd reading it will come down. Anyway after 1 month on the medication my joint pains has disappeared thanks to Methotrexate. I take 10mg once weekly with folic acid next day. Worked for me. YAY!

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